USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P38919 USC-OGP 2-DE database:  P38919 P38919 General information about the entry View entry in simple text format Entry name IF4A3_HUMAN Primary accession number P38919 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Eukaryotic initiation factor 4A-III; Short=eIF-4A-III; Short=eIF4A-III; EC=3.6.4.13; AltName: Full=ATP-dependent RNA helicase DDX48; AltName: Full=ATP-dependent RNA helicase eIF4A-3; AltName: Full=DEAD box protein 48; AltName: Full=Eukaryotic initiation factor 4A-like NUK-34; AltName: Full=Eukaryotic translation initiation factor 4A isoform 3; AltName: Full=Nuclear matrix protein 265; Short=NMP 265; Short=hNMP 265; Contains: RecName: Full=Eukaryotic initiation factor 4A-III, N-terminally processed;. Gene name Name=EIF4A3 Synonyms=DDX48, KIAA0111 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1172: pI=6.39; Mw=46315 Cross-references UniProtKB/Swiss-Prot P38919; IF4A3_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name IF4A3_HUMAN Primary accession number P38919 Secondary accession number(s) Q15033 Q6IBQ2 Q96A18 Sequence was last modified on  January 23, 2007 (version 4) Annotations were last modified on  March 15, 2017 (version 198) Name and origin of the protein Description RecName: Full=Eukaryotic initiation factor 4A-III; Short=eIF-4A-III; Short=eIF4A-III; EC=3.6.4.13; AltName: Full=ATP-dependent RNA helicase DDX48; AltName: Full=ATP-dependent RNA helicase eIF4A-3; AltName: Full=DEAD box protein 48; AltName: Full=Eukaryotic initiation factor 4A-like NUK-34; AltName: Full=Eukaryotic translation initiation factor 4A isoform 3; AltName: Full=Nuclear matrix protein 265; Short=NMP 265; Short=hNMP 265; Contains: RecName: Full=Eukaryotic initiation factor 4A-III, N-terminally processed; Gene name Name=EIF4A3 Synonyms=DDX48, KIAA0111 Encoded on Name=EIF4A3; Synonyms=DDX48, KIAA0111 Keywords 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Helicase; Hydrolase; Isopeptide bond; mRNA processing; mRNA splicing; mRNA transport; Nonsense-mediated mRNA decay; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; rRNA processing; Spliceosome; Translation regulation; Transport; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X79538; CAA56074.1; -; mRNA EMBL D21853; BAA04879.2; ALT_INIT; mRNA EMBL AK290608; BAF83297.1; -; mRNA EMBL CR456750; CAG33031.1; -; mRNA EMBL AC087741; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471099; EAW89584.1; -; Genomic_DNA EMBL BC003662; AAH03662.1; -; mRNA EMBL BC004386; AAH04386.1; -; mRNA EMBL BC011151; AAH11151.1; -; mRNA CCDS CCDS11767.1; -; . PIR S45142; S45142; . RefSeq NP_055555.1; NM_014740.3; . UniGene Hs.389649; -; . PDB 2HXY; X-ray; 3.30 A; A/B/C/D=23-411 PDB 2HYI; X-ray; 2.30 A; C/I=1-411 PDB 2J0Q; X-ray; 3.20 A; A/B=2-411 PDB 2J0S; X-ray; 2.21 A; A=2-411 PDB 2J0U; X-ray; 3.00 A; A/B=38-411 PDB 2XB2; X-ray; 3.40 A; A/X=1-411 PDB 3EX7; X-ray; 2.30 A; C/H=1-411 PDB 4C9B; X-ray; 2.00 A; A=1-411 PDBsum 2HXY; -; . PDBsum 2HYI; -; . PDBsum 2J0Q; -; . PDBsum 2J0S; -; . PDBsum 2J0U; -; . PDBsum 2XB2; -; . PDBsum 3EX7; -; . PDBsum 4C9B; -; . ProteinModelPortal P38919; -; . SMR P38919; -; . BioGrid 115119; 263; . DIP DIP-33218N; -; . IntAct P38919; 161; . MINT MINT-1460615; -; . STRING 9606.ENSP00000269349; -; . TCDB 3.A.18.1.1; the nuclear mrna exporter (mrna-e) family; . iPTMnet P38919; -; . PhosphoSitePlus P38919; -; . SwissPalm P38919; -; . BioMuta EIF4A3; -; . DMDM 20532400; -; . REPRODUCTION-2DPAGE IPI00009328; -; . EPD P38919; -; . MaxQB P38919; -; . PaxDb P38919; -; . PeptideAtlas P38919; -; . PRIDE P38919; -; . DNASU 9775; -; . Ensembl ENST00000269349; ENSP00000269349; ENSG00000141543; . GeneID 9775; -; . KEGG hsa:9775; -; . UCSC uc002jxs.3; human; . CTD 9775; -; . DisGeNET 9775; -; . GeneCards EIF4A3; -; . HGNC HGNC:18683; EIF4A3; . HPA HPA021878; -; . MalaCards EIF4A3; -; . MIM 268305; phenotype; . MIM 608546; gene; . neXtProt NX_P38919; -; . OpenTargets ENSG00000141543; -; . Orphanet 3102; Richieri Costa-Pereira syndrome; . PharmGKB PA162384945; -; . eggNOG KOG0327; Eukaryota; . eggNOG COG0513; LUCA; . GeneTree ENSGT00530000062880; -; . HOGENOM HOG000268797; -; . HOVERGEN HBG107989; -; . InParanoid P38919; -; . KO K13025; -; . OMA TATFCIS; -; . OrthoDB EOG091G07OI; -; . PhylomeDB P38919; -; . TreeFam TF300466; -; . BRENDA 3.6.4.13; 2681; . Reactome R-HSA-109688; Cleavage of Growing Transcript in the Termination Region; . Reactome R-HSA-1169408; ISG15 antiviral mechanism; . Reactome R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript; . Reactome R-HSA-429947; Deadenylation of mRNA; . Reactome R-HSA-72163; mRNA Splicing - Major Pathway; . Reactome R-HSA-72187; mRNA 3'-end processing; . Reactome R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); . ChiTaRS EIF4A3; human; . EvolutionaryTrace P38919; -; . GeneWiki EIF4A3; -; . GenomeRNAi 9775; -; . PRO PR:P38919; -; . Proteomes UP000005640; Chromosome 17; . Bgee ENSG00000141543; -; . CleanEx HS_EIF4A3; -; . ExpressionAtlas P38919; baseline and differential; . Genevisible P38919; HS; . GO GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:HGNC; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0030425; C:dendrite; IEA:Ensembl; . GO GO:0035145; C:exon-exon junction complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0043025; C:neuronal cell body; IEA:Ensembl; . GO GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005524; F:ATP binding; IDA:HGNC; . GO GO:0004004; F:ATP-dependent RNA helicase activity; IDA:HGNC; . GO GO:0003729; F:mRNA binding; IDA:UniProtKB; . GO GO:0008143; F:poly(A) binding; IDA:HGNC; . GO GO:0043021; F:ribonucleoprotein complex binding; IEA:Ensembl; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0035613; F:RNA stem-loop binding; IEA:Ensembl; . GO GO:0035368; F:selenocysteine insertion sequence binding; IEA:Ensembl; . GO GO:0008306; P:associative learning; IEA:Ensembl; . GO GO:1990416; P:cellular response to brain-derived neurotrophic factor stimulus; IEA:Ensembl; . GO GO:0072715; P:cellular response to selenite ion; IEA:Ensembl; . GO GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:UniProtKB; . GO GO:0035640; P:exploration behavior; IEA:Ensembl; . GO GO:0031124; P:mRNA 3'-end processing; TAS:Reactome; . GO GO:0006406; P:mRNA export from nucleus; TAS:Reactome; . GO GO:0000398; P:mRNA splicing; via spliceosome; IC:UniProtKB GO GO:0090394; P:negative regulation of excitatory postsynaptic potential; IEA:Ensembl; . GO GO:1904570; P:negative regulation of selenocysteine incorporation; IEA:Ensembl; . GO GO:1904574; P:negative regulation of selenocysteine insertion sequence binding; IEA:Ensembl; . GO GO:0017148; P:negative regulation of translation; IDA:HGNC; . GO GO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; IMP:UniProtKB GO GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome; . GO GO:0048026; P:positive regulation of mRNA splicing; via spliceosome; IEA:Ensembl GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl; . GO GO:0045727; P:positive regulation of translation; IMP:UniProtKB; . GO GO:0014070; P:response to organic cyclic compound; IEA:Ensembl; . GO GO:0006405; P:RNA export from nucleus; TAS:Reactome; . GO GO:0010501; P:RNA secondary structure unwinding; IBA:GO_Central; . GO GO:0008380; P:RNA splicing; IBA:GO_Central; . GO GO:0006364; P:rRNA processing; IEA:UniProtKB-KW; . GO GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome; . Gene3D 3.40.50.300; -; 2; . InterPro IPR011545; DEAD/DEAH_box_helicase_dom; . InterPro IPR014001; Helicase_ATP-bd; . InterPro IPR001650; Helicase_C; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR000629; RNA-helicase_DEAD-box_CS; . InterPro IPR014014; RNA_helicase_DEAD_Q_motif; . Pfam PF00270; DEAD; 1; . Pfam PF00271; Helicase_C; 1; . SMART SM00487; DEXDc; 1; . SMART SM00490; HELICc; 1; . SUPFAM SSF52540; SSF52540; 1; . PROSITE PS00039; DEAD_ATP_HELICASE; 1; . PROSITE PS51192; HELICASE_ATP_BIND_1; 1; . PROSITE PS51194; HELICASE_CTER; 1; . PROSITE PS51195; Q_MOTIF; 1; .

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